Peer-reviewed veterinary case report
Lower insulin signal gene activity in dogs with untreated
By Nozawa, Satoshi et al.·Published in The Journal of veterinary medical science·2014·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Decreased gene expressions of insulin signal molecules in canine hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of dogs with hyperadrenocorticism (HAC), a condition where the body produces too much cortisol, showed decreased levels of important insulin signaling molecules. This can lead to insulin resistance, making it harder for their bodies to manage blood sugar. The study compared untreated HAC dogs and those treated with trilostane, a common medication for this condition, and found that both groups had significantly lower gene expressions for several insulin-related proteins compared to healthy dogs. This suggests that HAC affects insulin function, which could be a concern for managing their overall health.
People also search for: dog hyperadrenocorticism symptoms · insulin resistance in dogs · trilostane for dog Cushing's disease
Abstract
Hyperadrenocorticism (HAC) is a common endocrine disorder in dogs, in which excess glucocorticoid causes insulin resistance. Disturbance of insulin action may be caused by multiple factors, including transcriptional modulation of insulin signal molecules which lie downstream of insulin binding to insulin receptors. In this study, gene expressions of insulin signal molecules were examined using neutrophils of the HAC dogs (the untreated dogs and the dogs which had been treated with trilostane). Insulin receptor substrate (IRS)-1, IRS-2, phosphatidylinositol 3-kinase (PI3-K), protein kinase B/Akt kinase (Akt)-2 and protein kinase C (PKC)-lambda were analyzed in the HAC dogs and compared with those from normal dogs. The IRS-1 gene expressions decreased by 37% and 35% of the control dogs in the untreated and treated groups, respectively. The IRS-2 gene expressions decreased by 61% and 72%, the PI3-K gene expressions decreased by 47% and 55%, and the Akt-2 gene expressions decreased by 45% and 56% of the control dogs, similarly. Collectively, gene expressions of insulin signal molecules are suppressed in the HAC dogs, which may partially contribute to the induction of insulin resistance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24829079/