Peer-reviewed veterinary case report
Enalapril lowers sympathetic tone in dogs with mild mitral valve
By Chompoosan, Chayanon et al.·Published in Research in veterinary science·2014·Faculty of Veterinary Science·View original on PubMed →
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Original publication title: Decreased sympathetic tone after short-term treatment with enalapril in dogs with mild chronic mitral valve disease.
- Species:
- dog
Plain-English summary
A group of 14 dogs with mild heart disease, specifically mitral regurgitation, were treated with a medication called enalapril for 14 days to see how it affected their heart function. After the treatment, the dogs showed improvements, including a decrease in heart size and blood pressure, along with better heart rate variability, which indicates improved heart health. The treatment helped reduce the workload on their hearts, making them more comfortable. Overall, the dogs responded well to enalapril, showing positive changes in their heart function.
People also search for: dog heart disease treatment · enalapril for dogs · mitral regurgitation in dogs · heart medication for dogs
Abstract
Heart rate variability (HRV) and echocardiography were performed in 14 dogs with mitral regurgitation (MR) before and after 14 days of 0.5mg/kg/day of enalapril treatment. All dogs were in heart failure stages B1 and B2. After enalapril treatment, left ventricular end diastolic diameter (LVEDd), left ventricular end diastolic diameter normalized for body weight (LVEDdN) and percent mitral regurgitant jet decreased (P<0.05). The diastolic blood pressure decreased (P<0.05). Increased time domain parameters of HRV were found. For frequency domain analysis, the total frequency (TF) increased significantly (P<0.05). The normalized low frequency (LF norm) decreased while normalized high frequency (HF norm) increased causing significant reduction in LF/HF (P<0.05). Before enalapril treatment, LF was correlated with end diastolic volume (EDV) (P<0.01) and LVEDd (P<0.05). In conclusion, MR dogs receiving enalapril treatment for 14 days had increased cardiac parasympathetic tone while sympathetic tone was suppressed. The decreased sympathetic activity corresponded to the reduction in cardiac preload and afterload.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24559801/