Peer-reviewed veterinary case report
Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis.
- Journal:
- Arteriosclerosis, thrombosis, and vascular biology
- Year:
- 2008
- Authors:
- Ait-Oufella, Hafid et al.
- Affiliation:
- Inserm U689 · France
- Species:
- rodent
Abstract
OBJECTIVE: To study the role of Mer receptor tyrosine kinase (mertk) in atherosclerosis. METHODS AND RESULTS: We irradiated and reconstituted atherosclerosis-susceptible C57Bl/6 low-density lipoprotein receptor-deficient female mice (ldlr(-/-)) with either a mertk(+/+) or mertk(-/-) (tyrosine kinase-defective mertk) bone marrow. The mice were put on high-fat diet for either 8 or 15 weeks. Mertk deficiency led to increased accumulation of apoptotic cells within the lesions, promoted a proinflammatory immune response, and accelerated lesion development. CONCLUSIONS: Mertk expression by bone marrow-derived cells is required for the disposal of apoptotic cells and controls lesion development and inflammation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18467644/