Peer-reviewed veterinary case report
Deletion of rgaS reduces virulence in a mouse model of Clostridioides difficile infection.
- Journal:
- Anaerobe
- Year:
- 2025
- Authors:
- Bilverstone, Terry W et al.
- Affiliation:
- Biodiscovery Institute · United Kingdom
Abstract
Two-component system signalling is involved in several processes relevant to Clostridioides difficile virulence. We demonstrate that deletion of the orphan histidine kinase rgaS (R20291_0503), reduces detectable toxin in the supernatant of R20291 and impairs virulence in a mouse model of infection. These data suggest that RgaS regulates virulence capabilities in hypervirulent C. difficile.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40789516/