Peer-reviewed veterinary case report
Antibiotic resistance patterns in dog infections at a veterinary
By Leet-Otley, Kendall et al.·Published in Journal of the American Veterinary Medical Association·2023·1Cummings School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Demonstrating the importance of local culture and susceptibility data: antibiograms from dogs at a veterinary tertiary care center.
- Species:
- dog
Plain-English summary
A study looked at bacteria from urine, skin, and respiratory samples taken from dogs at a veterinary hospital to see how well they responded to common antibiotics. They found that a type of bacteria called Escherichia coli from urine was more likely to respond to a combination antibiotic (amoxicillin-clavulanate) than to amoxicillin alone. However, many skin infections caused by Staphylococcus pseudintermedius were resistant to methicillin, which is a concern for treatment options. This research emphasizes the importance of knowing local bacteria resistance patterns to choose the best antibiotics for dogs.
People also search for: dog skin infection treatment · antibiotic resistance in dogs · urinary tract infection in dogs antibiotics
Abstract
OBJECTIVE: To create antibiograms for commonly cultured organisms in a small animal tertiary care hospital following Clinical and Laboratory Standards Institute guidelines and to compare these local resistance patterns to published first-tier antimicrobial recommendations. SAMPLE: Urine (n = 429), respiratory (41), and skin (75) isolates cultured from dogs between January 1, 2019, and December 31, 2020, at the Tufts University Foster Hospital for Small Animals. PROCEDURES: MIC and susceptibility interpretations were recorded for multiple sites for 2 years. Sites with greater than 30 isolates for at least 1 organism were included. Urinary, respiratory, and skin antibiograms were created using Clinical and Laboratory Standards Institute breakpoints and guidelines. RESULTS: Urinary Escherichia coli had a higher susceptibility percentage for amoxicillin-clavulanate (80% [221/275]) than amoxicillin alone (64% [175/275]). Respiratory E coli were greater than 80% susceptible to only 2 antimicrobials (imipenem, amikacin). Of skin Staphylococcus pseudintermedius isolates, 40% (30/75) were methicillin-resistant and frequently also displayed resistance to non-beta lactam antimicrobials. Susceptibility to recommended first-line antimicrobials varied and was greatest for gram-negative urinary isolates and lowest for methicillin-resistant S pseudintermedius skin isolates and respiratory E coli. CLINICAL RELEVANCE: Local antibiogram creation identified frequent resistance that may preclude the use of guideline-recommended first-line therapy. High levels of resistance identified in methicillin-resistant S pseudintermedius isolates supports growing concern for methicillin-resistant staphylococci in veterinary patients. This project highlights the need for population-specific resistance profiles to be used in conjunction with national guidelines.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36862544/