Peer-reviewed veterinary case report
Dog nasal vaccine protects against Bordetella bronchiseptica for 1
By Lehar, Craig et al.·Published in Veterinary therapeutics : research in applied veterinary medicine·2008·Intervet/Schering-Plough Animal Health, United States·View original on PubMed →
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Original publication title: Demonstration of 1-year duration of immunity for attenuated Bordetella bronchiseptica vaccines in dogs.
- Species:
- dog
Plain-English summary
A group of healthy dogs received a vaccine to protect against Bordetella bronchiseptica, which causes kennel cough. After vaccination, these dogs developed strong immunity that lasted for at least a year. When they were later exposed to the bacteria, the vaccinated dogs showed fewer signs of illness and spread less of the bacteria compared to unvaccinated dogs. This means that a single dose of this vaccine can effectively protect dogs from kennel cough for a full year.
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Abstract
Three groups of healthy dogs with low antibody titers to Bordetella bronchiseptica (Bb), canine parainfluenza virus (CPI), and canine adenovirus type 2 (CAV-2) were used in this study. One group was vaccinated with a single dose of monovalent attenuated Bb vaccine and one group with a trivalent vaccine containing attenuated Bb, CPI, and CAV-2; dogs were vaccinated intranasally with a single dose of the respective vaccines. The third group served as unvaccinated controls. All vaccinated dogs subsequently developed serum antibody titers to Bb that persisted for at least 1 year. Following Bb challenge 1 year after vaccination, all vaccinated dogs, regardless of group, showed significantly fewer clinical signs and shed significantly fewer challenge organisms than unvaccinated controls. These results demonstrate that intranasal administration of a single dose of monovalent attenuated Bb vaccine or trivalent vaccine containing attenuated Bb, CPI, and CAV-2 provides 1 year of protection against Bb.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19177330/