Peer-reviewed veterinary case report
More granzyme B immune cells mean better outlook for dogs
By Inoue, Akiko et al.·Published in Veterinary immunology and immunopathology·2017·Department of Veterinary Clinical Pathobiology, Japan·View original on PubMed →
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Original publication title: Density of tumor-infiltrating granzyme B-positive cells predicts favorable prognosis in dogs with transitional cell carcinoma.
- Species:
- dog
Plain-English summary
A study found that dogs with transitional cell carcinoma (TCC), a type of bladder cancer, had better outcomes when their tumors contained a high number of granzyme B-positive immune cells. These cells are part of the body's defense against cancer. In the research, dogs with more of these granzyme B-positive cells showed a favorable prognosis, suggesting that they might help slow down tumor growth. This information could be useful for veterinarians when assessing the prognosis of dogs diagnosed with TCC.
People also search for: dog bladder cancer prognosis · transitional cell carcinoma in dogs · granzyme B in dog tumors
Abstract
Although tumor-infiltrating lymphocytes (TILs) play a key role in anti-tumor immunity, their involvement in canine transitional cell carcinoma (TCC) is not well-documented. The objective of this study was to investigate the association between TIL number and prognosis in dogs with urinary bladder TCC. Immunohistochemical analysis of CD3 and granzyme B was performed using canine TCC (n=32) and normal bladder (n=10) tissues. The numbers of CD3and granzyme Bcells located in peritumoral stroma of canine TCC were significantly higher than those in normal controls. In TCC cases, the number of CD3TILs was not significantly related to prognosis, whereas the abundant granzyme BTILs were associated with favorable outcome. Since granzyme BTILs were not associated with the tumor stage, the presence of granzyme BTILs may be an independent prognostic factor. These results suggest that granzyme BTILs play a role in anti-tumor immunity and inhibit tumor progression in canine TCC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28778323/