Peer-reviewed veterinary case report
Dental erosion in a Chihuahua after clopidogrel medicine
By Kim, Se Eun·Published in Veterinary medicine and science·2024·Department of Veterinary Clinical Sciences, South Korea·View original on PubMed →
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Original publication title: Dental erosion following clopidogrel administration in a dog: A case-based study.
- Species:
- dog
Plain-English summary
A 10-year-old neutered male Chihuahua developed dental erosion after taking clopidogrel, a medication mixed with honey for several months. Tests showed that clopidogrel was acidic and likely contributed to the damage to the dog's teeth. Further experiments with extracted teeth confirmed that soaking them in a clopidogrel-honey mixture caused significant surface roughness and changes in mineral content. This suggests that long-term use of clopidogrel could lead to dental problems in dogs.
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Abstract
A 10-year-old neutered male Chihuahua presented with unilateral dental erosion that occurred after several months of oral medications mixed with honey. A pH test was performed on all oral medications administered to the dogs to determine the cause of enamel erosion. Among the medications, the only acidic medication was clopidogrel (pH 2.65). To evaluate the effect of clopidogrel on the tooth surface under the same conditions as in the present patient, an additional preliminary study was designed in which two extracted teeth of another dog were immersed in a clopidogrel-honey mixture or only in honey. After a 3-week soaking of the extracted tooth in the clopidogrel-honey mixture, field-emission scanning electron microscope analysis revealed a rougher surface, whereas energy-dispersive X-ray spectroscopy analysis showed a reduced Ca/C ratio compared to the control tooth. In this case, prolonged exposure of the tooth surface to clopidogrel may be a cause of dental erosion.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38376062/