Peer-reviewed veterinary case report
How cyclosporin A affects skin allergy chemicals in dogs
By Brazís, Pilar et al.·Published in Veterinary dermatology·2006·UNIVET Servicio de Diagnostico Veterinario SL, Spain·View original on PubMed →
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Original publication title: Dermal microdialysis in the dog: in vivo assessment of the effect of cyclosporin A on cutaneous histamine and prostaglandin D2 release.
- Species:
- dog
Plain-English summary
Four beagle dogs with allergic reactions were treated with cyclosporin A, a medication commonly used for skin allergies, to see how it affected their allergic responses. After one month of treatment, the dogs showed significantly lower levels of histamine, a chemical that causes itching and swelling, when tested with allergens. However, another inflammatory substance, prostaglandin D2, did not show a significant decrease. This suggests that cyclosporin A effectively reduces certain allergic symptoms in dogs, confirming its role as an anti-inflammatory treatment for skin allergies.
People also search for: dog skin allergy treatment · beagle itching relief · cyclosporin A for dog allergies
Abstract
Dermal microdialysis, a relatively noninvasive technique, allows investigation of the changes in cellular mediators released during cutaneous allergic responses. This technique was used to evaluate the effect of cyclosporin A, an immunosuppressive drug used for treatment of canine atopic dermatitis, on the cutaneous release of two pro-inflammatory mediators following intradermal allergen challenge. Four beagle dogs spontaneously sensitized to Ascaris suum were treated for 1 month with oral cyclosporin A. At days 0, 15 and 30 of the treatment, dialysis probes were inserted into the skin of the back, and 20 microL of A. suum antigen was injected intradermally at each site. At timed intervals, dialysate was collected and assayed for histamine and prostaglandin D(2) and the wheal area was measured. Mean histamine concentration and wheal area were significantly lower at days 15 and 30 of treatment, compared with day 0. However, prostaglandin D(2) concentration was not significantly reduced. The inhibition in histamine release after intradermal challenge, by cyclosporin, confirms its anti-inflammatory action in the dog. Dermal microdialysis provides a useful tool for investigating canine allergic reactions and their modulation by drugs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16674731/