Peer-reviewed veterinary case report
How skin biopsy sections help diagnose alopecia X hair loss
By Zanna, Giordana et al.·Published in Veterinary dermatology·2024·Anicura-Istituto Veterinario di Novara, Italy·View original on PubMed →
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Original publication title: Dermoscopic findings and comparison of usefulness of longitudinal versus transversal sections in the histological diagnosis of alopecia X.
- Species:
- dog
Plain-English summary
Nineteen Pomeranian dogs with a condition called alopecia X, which causes hair loss, were studied to better understand how to diagnose it. The dogs showed symptoms like thinning hair, scaling, and dark spots on their skin. Researchers compared two methods of examining skin samples and found that using transversal (cross-section) cuts of the skin provided more accurate information about hair follicle density and health than longitudinal (lengthwise) cuts. This study suggests that combining skin examinations with these different biopsy techniques can help veterinarians diagnose alopecia X more effectively.
People also search for: Pomeranian hair loss treatment · alopecia X in dogs · skin biopsy for dog hair loss
Abstract
BACKGROUND: A combination of dermoscopic and histological findings may provide useful information for the diagnosis of hair follicle diseases. However, there are no studies on dermoscopic-histopathological correlations in dogs affected by alopecia X, and comparison of longitudinal versus transversal sectioning of skin biopsy specimens in the assessment of this hair loss disorder has not been thoroughly investigated. HYPOTHESIS/OBJECTIVES: The aim of this study was to correlate dermoscopic and histological features using both longitudinal and transversal sectioning of skin biopsy samples to gain additional information for the diagnosis of alopecia X. ANIMALS: Nineteen Pomeranian dogs affected by alopecia X and five healthy Pomeranians as controls. MATERIALS AND METHODS: Dermoscopic-histological correlation was performed within the diseased group, whereas histological comparisons against controls. The demographic and clinical characteristics also were related to the histological findings. RESULTS: The dermoscopic findings revealed scattered, thinned, short hairs mixed with amorphous keratoseborrhoeic-like material (follicular plugging), perifollicular and intrafollicular scaling, and hyperpigmentation varying from pinpoint black spots to a diffuse texture. Dermoscopic findings correlated with histological findings for selected qualitative and quantitative findings. The usefulness of transversal sections was demonstrated in accurately determining the hair follicular density and counts, growth arrest phases and in identifying mineralisation of hair follicle basement membrane when compared to the longitudinal. Conversely, no correlations between histological findings and demographic and clinical characteristics were detected. CONCLUSIONS AND CLINICAL RELEVANCE: These data provide evidence of the usefulness of dermoscopic evaluation as an accessory diagnostic tool and of transversal sections of skin biopsies as complementary to the diagnosis of alopecia X.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37867253/