Design of a quinoxalinone-based AIE probe for the detection of ROS inandsepsis models.

Abstract

Sepsis is one of the major causes of long-term mortality; the identification of potential biomarkers and developing specific and sensitive imaging and detection methods are crucial for timely diagnosis and progression evaluation. Reactive oxygen species (ROS) may serve as a potential detection and imaging marker for sepsis. Herein, we designed and synthesized a near-infrared quinoxalone framework-based aggregation-induced emission probe (QuinoNS NPs). We evaluated the selectivity, cytotoxicity, and detection and imaging ability in anLPS induced inflammatory model and ansepsis model. The probe can respond to ROS, causing a blue shift in the fluorescence emission wavelength. The probe can achieve real-time imaging and detection of ROS in LPS induced sepsis models bothandwith quick response and a superior duration time without significant toxicity. This study provides new strategies and theoretical basis for imaging and diagnosis of inflammatory diseases such as sepsis.