Peer-reviewed veterinary case report
Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.
- Journal:
- Farmaco (Societa chimica italiana : 1989)
- Year:
- 2004
- Authors:
- Zhao, Long-Xuan et al.
- Affiliation:
- Department of Chemistry · China
Abstract
For the development of new anticonvulsive agents, analogs of gamma-vinyl GABA (vigabatrin) containing GABA, gamma-vinyl GABA, valproic acid, nipecotic acid or isonipecotic acid moieties were prepared and evaluated for their anticonvulsive activities. Most of the prepared compounds showed moderate anticonvulsive activities. Among them compounds 10 and 16 displayed the most potent anticonvulsive activity and a broader spectrum compared to vigabatrin.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15120317/