Peer-reviewed veterinary case report
Design, synthesis and biological evaluation of peptide derivatives of L-dopa as anti-parkinsonian agents.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2013
- Authors:
- Zhou, Tao et al.
- Affiliation:
- School of Food Science and Biotechnology · China
- Species:
- rodent
Abstract
A series of dipeptide derivatives of L-dopa were synthesized and investigated for their pharmacological activity using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat as an experimental model of Parkinson's disease. Among them, (S)-isopropyl 2-(2-amino-2-methylpropanamido)-3-(3,4-dihydroxyphenyl)propanoate (4 g) was found to be the most active compound, with 106% AUC activity and 149% peak activity of L-dopa after oral administration.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23973169/