Peer-reviewed veterinary case report
MYBPC3 gene changes linked to heart disease in Persian cats
By Heydaryan, Saeed et al.·Published in Iranian Journal of Veterinary Medicine·2024·View original on Crossref →
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Original publication title: Detecting Polymorphism of Myosin-binding Protein C3 Gene in Persian Breed Cat With and Without Hypertrophic Cardiomyopathy
- Species:
- cat
Plain-English summary
A group of Persian cats, some with hypertrophic cardiomyopathy (HCM), a common heart disease, were tested to see if a specific gene mutation was responsible for their condition. Researchers collected blood samples from 7 affected cats and 2 healthy ones, looking for changes in the MYBPC3 gene that could cause HCM. While they found several genetic variations, none were linked to the heart disease in these cats. This suggests that other genetic factors may contribute to HCM in Persian cats, and further research is needed to identify them.
People also search for: Persian cat heart disease symptoms · hypertrophic cardiomyopathy in cats · genetic testing for cat heart disease
Abstract
Background: In cats, hypertrophic cardiomyopathy (HCM) stands out as a prevailing heart disease. The mutations in the gene that encodes cardiac myosin-binding protein C (MYBPC3) have been detected in the Ragdoll and Maine Coon breeds. Objectives: HCM is believed to be hereditary in other breeds, too. Methods: Blood samples were collected for DNA extraction from 2 unaffected and 7 affected Persian breed cats with HCM. Besides accomplishing conventional polymerase chain reaction, DNA sequencing was performed. The sequence changes were utilized to detect single nucleotide polymorphisms in the MYBPC3 gene and predict amino acid substitutions based on the Acc. No. XM_019812396.1 and comparisons with the literature on identified breed variants and control samples. Results: Although many single nucleotide polymorphisms were found in the affected and unaffected Persian cats, no causative mutation for HCM was observed. Conclusion: In this breed, HCM does not seem to be caused solely by mutations in this cardiac gene. Potential cardiac genes should be investigated to uncover other genetic reasons for this cardiac disease in the Persian cat breed.
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Search related cases →Original publication on Crossref: https://doi.org/10.32598/ijvm.18.2.1005356