Peer-reviewed veterinary case report
Viruses causing diarrhea in puppies found by advanced genetic testing
By Bhatta, Tarka Raj et al.·Published in Scientific Reports·2019·View original on Crossref →
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Original publication title: Detection and characterisation of canine astrovirus, canine parvovirus and canine papillomavirus in puppies using next generation sequencing
- Species:
- dog
Plain-English summary
A group of puppies from a kennel in Victoria, Australia, were suffering from diarrhea and were tested for possible infections. Researchers found that a canine astrovirus was likely causing the gastroenteritis, along with a vaccine strain of canine parvovirus and some canine papillomaviruses. The puppies were treated based on these findings, and the use of advanced testing methods helped identify the specific viruses involved. This approach could help vets better understand and treat similar cases in the future.
People also search for: puppy diarrhea causes · canine astrovirus treatment · gastroenteritis in puppies · dog kennel infections · canine parvovirus vaccine strain
Abstract
AbstractGastroenteritis in young animals is a clinical presentation with many infectious and non- infectious aetiologies. We used next generation sequencing (NGS) to investigate the possible infectious causes of gastroenteritis in puppies from a dog kennel in Victoria, Australia. The near complete genome of a canine astrovirus was obtained from pooled faecal samples, and was found to be 94.7% identical with a canine astrovirus detected in the United Kingdom in 2012. The phylogenetic analysis of the capsid gene found similarities to those of canine astroviruses identified in Italy in 2005 and in UK and Hungary in 2012, but distant from that of a canine astrovirus previously identified in Australia in 2012. Thus, different serotypes of canine astrovirus are likely circulating in Australia. The close relationship to European astroviruses also suggested that there had been recent movements of ancestor canine astroviruses between Australia and Europe. NGS also detected other infections in the puppies including several canine papillomaviruses and a canine parvovirus (vaccine strain) as well as a very low level of campylobacter. Canine astrovirus was the probable cause of diarrhoea in these puppies, with the possible involvement of campylobacter bacteria. NGS was effective as a non-targeted method to determine the likely infectious cause of gastroenteritis.
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Search related cases →Original publication on Crossref: https://doi.org/10.1038/s41598-019-41045-z