Peer-reviewed veterinary case report
Viruses linked to puppy diarrhea found by advanced genetic testing
By Bhatta, Tarka Raj et al.·Published in Scientific reports·2019·Geelong Centre for Emerging Infectious Diseases, Australia·View original on PubMed →
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Original publication title: Detection and characterisation of canine astrovirus, canine parvovirus and canine papillomavirus in puppies using next generation sequencing.
- Species:
- dog
Plain-English summary
A group of puppies from a kennel in Victoria, Australia, was suffering from diarrhea and vomiting due to gastroenteritis. Testing revealed that a canine astrovirus was likely the main cause, along with a vaccine strain of canine parvovirus and some canine papillomaviruses. The researchers used advanced sequencing techniques to identify these infections, which helped pinpoint the cause of the puppies' symptoms. Understanding the specific viruses involved can help veterinarians provide better care and treatment for affected puppies.
People also search for: puppy diarrhea causes · canine astrovirus symptoms · gastroenteritis treatment in puppies
Abstract
Gastroenteritis in young animals is a clinical presentation with many infectious and non- infectious aetiologies. We used next generation sequencing (NGS) to investigate the possible infectious causes of gastroenteritis in puppies from a dog kennel in Victoria, Australia. The near complete genome of a canine astrovirus was obtained from pooled faecal samples, and was found to be 94.7% identical with a canine astrovirus detected in the United Kingdom in 2012. The phylogenetic analysis of the capsid gene found similarities to those of canine astroviruses identified in Italy in 2005 and in UK and Hungary in 2012, but distant from that of a canine astrovirus previously identified in Australia in 2012. Thus, different serotypes of canine astrovirus are likely circulating in Australia. The close relationship to European astroviruses also suggested that there had been recent movements of ancestor canine astroviruses between Australia and Europe. NGS also detected other infections in the puppies including several canine papillomaviruses and a canine parvovirus (vaccine strain) as well as a very low level of campylobacter. Canine astrovirus was the probable cause of diarrhoea in these puppies, with the possible involvement of campylobacter bacteria. NGS was effective as a non-targeted method to determine the likely infectious cause of gastroenteritis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30872719/