Peer-reviewed veterinary case report
Leptospirosis bacteria found in dogs with kidney or liver disease
By Rahman, Sabri A et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2021·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Detection and characterization ofspp. in dogs diagnosed with kidney and/or liver disease in Selangor, Malaysia.
- Species:
- dog
Plain-English summary
A group of 124 pet dogs in Malaysia with kidney and/or liver disease was tested for leptospirosis, a serious bacterial infection. Out of these dogs, 53 tested positive for exposure to the bacteria, with the most common types being Bataviae, Javanica, and Icterohaemorrhagiae. Additionally, tests showed that a significant number of blood and urine samples were also positive for the bacteria. Unfortunately, the study found a high mortality rate among the infected dogs, with 34% not surviving. This highlights the importance of testing and treating dogs with kidney or liver issues for leptospirosis.
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Abstract
Leptospirosis is a serious bacterial disease that affects both humans and animals. A wide range of symptoms have been described in humans; the disease in dogs is commonly associated with kidney and/or liver disease. In Malaysia, information about the common serovars infecting dogs is limited. Therefore, we investigated the occurrences of leptospirosis in 124 pet dogs diagnosed with kidney and/or liver disease. Blood, urine, abdominal effusion, and/or kidney and liver were collected from the dogs. Based on microscopic agglutination testing, 53 of 124 (42.7%) dogs were seropositive for leptospiral exposure. Sera were frequently positive to serovars Bataviae ( = 12), Javanica ( = 10), and Icterohaemorrhagiae ( = 10). Direct detection using PCR showed that 42 of 124 (33.9%) of the whole blood and 36 of 113 (31.9%) urine samples were positive for pathogenicspp. By PCR, 2 of 23 (9.1%) kidney and 2 of 23 (9.1%) liver were positive for pathogenicspp. Abdominal effusion from 4 dogs were PCR-positive for pathogenicspp. The species detected were,,, andby partial 16S rRNA sequencing. We further identified and characterized 11spp. isolates from 8 dogs as serovars Bataviae, Javanica, and Australis. The mortality rate of the-infected dogs was high (18 of 53; 34%).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34148436/