Peer-reviewed veterinary case report
Fatal infectious canine hepatitis in a 4-month-old dog in India
By Syamily, Shaji et al.·Published in Veterinary Record Case Reports·2023·College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookot, Lakkidi Wayanad Kerala India, India·View original on Crossref →
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Original publication title: Detection and molecular characterisation of canine adenovirus type 1 from a fatal case of infectious canine hepatitis from India
- Species:
- dog
Plain-English summary
A 4-month-old male Rajapalayam puppy was brought in with severe symptoms of infectious canine hepatitis, which is caused by canine adenovirus type 1 (CAdV-1). Unfortunately, the puppy was unvaccinated and did not survive the illness. A postmortem examination confirmed the presence of the virus, and further tests showed that the strain was closely related to a similar virus found in a fox in the UK. This case highlights the importance of vaccination to protect dogs from serious viral infections like CAdV-1.
People also search for: puppy infectious canine hepatitis symptoms · unvaccinated dog adenovirus · canine hepatitis treatment options
Abstract
Abstract Canine adenovirus (CAdV), a non‐enveloped, linear dsDNA virus, is a member of the genus Mastadenovirus of the family Adenoviridae. Two different serotypes of CAdVs, canine adenovirus type 1 (CAdV‐1), which causes infectious canine hepatitis (ICH), and canine adenovirus type 2 (CAdV‐2), which causes canine infectious laryngotracheitis, have been identified in dogs. In this report, we discuss a case of fatal CAdV‐1 infection in a 4‐month‐old, male, unvaccinated, Rajapalayam breed dog. Postmortem examination results were suggestive of CAdV‐1 infection, which was confirmed by histopathological examination, molecular characterisation and phylogenetic analysis. Sequence analysis of the CAdV‐1 strain showed a close similarity with the Australasian‐Europe cluster, a high identity (99.78% nucleotide and 98.91% amino acid identities) with a CAdV‐1 isolate (KU75571) from a fox in the United Kingdom, and a unique substitution (W126S) in the E3 protein encoding sequence.
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Search related cases →Original publication on Crossref: https://doi.org/10.1002/vrc2.698