Peer-reviewed veterinary case report
Multidrug-resistant bacterial infection caused cat's death
By Valencia-Bacca, Juan et al.·Published in Microbial drug resistance (Larchmont, N.Y.)·2020·Department of Preventive Veterinary Medicine and Animal Health, Brazil·View original on PubMed →
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Original publication title: Detection and Whole-Genome Analysis of a High-Risk Clone ofST340/CG258 Producing CTX-M-15 in a Companion Animal.
- Species:
- cat
Plain-English summary
A domestic cat was diagnosed with a severe infection caused by a multidrug-resistant bacteria that produced a specific enzyme (CTX-M-15) making it resistant to many antibiotics. Unfortunately, despite treatment efforts, the infection was too aggressive, leading to the cat's death. This case highlights the importance of monitoring antibiotic-resistant infections not just in humans but also in pets, as they can pose significant health risks.
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Abstract
The emergence and dissemination of high-risk clones ofproducing extended-spectrum β-lactamases (ESBLs) in animal infections is a critical issue. We report the detection and genomic features of a multidrug-resistant (MDR) ESBL (CTX-M-15)-producinginfecting a domestic cat. Whole-genome sequencing analysis identified the international ST340 (clonal group CG258), and genes and mutations conferring resistance to β-lactams, aminoglycosides, macrolides, phenicols, fosfomycin, sulfonamides, tetracycline, trimethoprim, and fluoroquinolones. In addition, the presence of genes encoding resistance to disinfectant and heavy metals hazardous to humans was also confirmed. The MDR profile exhibited by the strain contributed to treatment failure and death of the companion animal. Therefore, active surveillance of critical priority lineages ofshould not only focus on human infections but also on veterinary infections.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31809242/