Peer-reviewed veterinary case report
Detection of canine distemper virus (CDV) neutralising antibodies in small ruminants during peste-des-petits-ruminants virus (PPRV) surveillance in Zambia.
- Journal:
- BMC veterinary research
- Year:
- 2025
- Authors:
- Lysholm, Sara et al.
- Affiliation:
- Department of Clinical Sciences
- Species:
- dog
Abstract
Canine distemper virus (CDV) is endemic in Zambia, while peste-des-petits-ruminants virus (PPRV) has not been detected. This study screened 962 farmed goats and 237 small ruminants at informal markets for PPRV antibodies using c-ELISA. A subset (n = 29) was re-analysed with virus neutralisation assays (VNA) for antibodies to PPRV and CDV due to cross-reactivity concerns. c-ELISA indicated 6.44% PPRV seroprevalence on farms and 3.80% at markets. While VNA detected no PPRV antibodies, 45% (13/29) tested positive for CDV, possibly suggesting cross-reactivity. Given the study's limitations, further research is needed to determine whether PPRV is present in Zambia and assess potential cross-reactivity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40307785/