Peer-reviewed veterinary case report
Canine oral papillomavirus found in dog eye growths
By Brandes, K et al.·Published in Veterinary pathology·2009·Animal Pathology, Germany·View original on PubMed →
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Original publication title: Detection of canine oral papillomavirus DNA in conjunctival epithelial hyperplastic lesions of three dogs.
- Species:
- dog
Plain-English summary
Three dogs were found to have unusual growths on their eyes, specifically conjunctival plaques and papillomas, which are benign tumors. Tests showed that these growths contained DNA from canine oral papillomavirus (COPV), a virus that can cause similar lesions on the skin and mucous membranes. While these lesions are generally not harmful, there is a possibility they could become more serious over time. The dogs were monitored, and the findings suggest that pet owners should be aware of these types of growths and consult their veterinarian if they notice any changes in their dog's eyes.
People also search for: dog eye growths · canine papillomavirus symptoms · conjunctival papilloma treatment
Abstract
Papillomavirus infections are responsible for plaques and papillomas in various locations on the skin and in mucous membranes. The aim of this report was to describe morphologic features of a viral pigmented conjunctival plaque and 2 conjunctival squamous papillomas in 3 dogs, and to investigate these lesions for the presence of papillomavirus DNA by polymerase chain reaction (PCR), DNA sequence analysis, and in situ hydridization (ISH). Histopathology revealed in all neoplasms various degrees of epithelial hyperplasia, acanthosis, and hyperkeratosis with koilocytosis. In all lesions E6, E7, and L1 gene fragments of canine oral papillomavirus (COPV) DNA were detected by PCR and sequencing analysis. ISH revealed COPV DNA in a highly specific pattern within nuclei of the hyperplastic epithelium. The presence of canine papillomavirus in ocular conjunctival plaques and papillomas suggests these benign lesions may have the potential for malignant transformation. This is the first time that the lambdapapillomavirus COPV has been detected in ocular epithelial hyperplastic lesions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19112112/