Peer-reviewed veterinary case report
Proteins causing allergic reactions found in hydrolysed dog foods
By Roitel, Olivier et al.·Published in Veterinary dermatology·2017·Genclis SA, France·View original on PubMed →
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Original publication title: Detection of IgE-reactive proteins in hydrolysed dog foods.
- Species:
- dog
Plain-English summary
A study found that some commercial hydrolyzed dog foods, which are often used to diagnose food allergies in dogs, may still contain proteins that could trigger allergic reactions. These proteins were detected in all three diets tested, and some dogs had antibodies in their blood that reacted to them. While the exact impact of these findings on dog health is unclear, it raises concerns for dogs with food allergies. If your dog is on a hydrolyzed diet and shows signs of allergies, it might be worth discussing this with your veterinarian.
People also search for: dog food allergy symptoms · hydrolyzed diet for dogs · dog allergy treatment
Abstract
BACKGROUND: Commercial hydrolysed diets are used for the diagnosis of food allergy in dogs. The cleaved parent proteins are presumed to be too small to elicit an allergic response by reacting with allergen-specific immunoglobin E (IgE). OBJECTIVES: To evaluate three commercial hydrolysed dog diets for proteins. ANIMALS: Sera were collected from dogs with suspected food allergy. METHODS: Two batches of each hydrolysed diet were examined by electrophoresis and visualized by Coomassie blue, silver nitrate staining and IgE immunoblotting. RESULTS: From two to five proteins, ranging from 21 to 67 kDa, were detected in all three diets evaluated. Circulating IgE antibodies targeting these proteins were detected by immunoblotting of dog sera. Six different carbohydrate proteins were identified by mass spectrometry; maize/potato granule-bound starch synthase-1, soybean glycinin, soybean β-conglycinin α chain, potato aspartic protease inhibitor, rice glutelin type B1 and soybean sucrose-binding protein. Four of these proteins have been described as allergens in humans. CONCLUSIONS: Some commercial hydrolysed diets contain carbohydrate proteins. Some dogs have circulating IgE antibodies targeting these proteins. The clinical significance of these findings is unknown.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28770578/