Peer-reviewed veterinary case report
Drug-resistant Klebsiella pneumoniae found in infected dog in Brazil
By Sellera, Fábio P et al.·Published in Transboundary and emerging diseases·2021·Department of Internal Medicine, Brazil·View original on PubMed →
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Original publication title: Detection of IncN-pST15 one-health plasmid harbouring blain a hypermucoviscous Klebsiella pneumoniae CG258 isolated from an infected dog, Brazil.
- Species:
- dog
Plain-English summary
A dog in Brazil was diagnosed with a urinary tract infection caused by a strain of Klebsiella pneumoniae that produces a dangerous enzyme called KPC-2, which makes it resistant to many antibiotics. This particular strain is known for being hypermucoviscous, meaning it can form thick, sticky colonies that are hard to treat. The research indicates that this type of bacteria can spread between pets and humans, raising concerns about public health. Treatment options for this infection may be limited due to the antibiotic resistance, so it's crucial for pet owners to be aware of the risks and discuss appropriate treatments with their veterinarian.
People also search for: dog urinary tract infection treatment · antibiotic-resistant bacteria in pets · Klebsiella pneumoniae in dogs
Abstract
The emergence and rapid spread of carbapenemase-producing Enterobacterales represents a serious public health concern. Critically, these global priority bacteria have begun to be reported in companion animals, implying a potential risk of cross-transmission between humans and pets. Using long-read (MinION) and short-read (Illumina) sequencing technologies, we have identified and characterized a hypermucoviscous KPC-2-producing Klebsiella pneumoniae strain belonging to the high-risk international clone ST11/CG258, in a dog with urinary tract infection. Strikingly, the blagene was carried by a 54-kb IncN plasmid assignated to ST15, which shared 99.8 and 96.8% pairwise identity with IncN-pST15 plasmids from human and environmental K. pneumoniae strains, respectively; all come from an area with high endemicity of KPC-2. Our findings suggest that IncN-pST15 plasmids conferring carbapenem resistance can play as important a role as clonal transmission of K. pneumoniae, representing another major challenge for One Health.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33507616/