Peer-reviewed veterinary case report
Non-primate hepacivirus found in UK dogs with respiratory disease
By El-Attar, L M R et al.·Published in Virology·2015·Royal Veterinary College, United Kingdom·View original on PubMed →
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Original publication title: Detection of non-primate hepaciviruses in UK dogs.
- Species:
- dog
Plain-English summary
A group of dogs in a rehoming kennel in the UK showed signs of respiratory disease, and researchers found a virus called non-primate hepacivirus (NPHV) in some of their tissues. Out of 210 dogs tested, 48 had the virus in their trachea, and 12 had it in their liver or lungs as well. While the presence of this virus was confirmed, the connection between the virus and the severity of respiratory symptoms wasn't clear. More research is needed to understand how this virus affects dogs and if it causes health problems.
People also search for: dog respiratory disease UK · non-primate hepacivirus in dogs · dog kennel cough symptoms
Abstract
Non-primate hepacivirus (NPHV) has been identified in dogs, horses, bats and wild rodents. The presence of NPHV in dogs outside of the USA however is yet to be established. Here we describe for the first time the detection of NPHV in the UK dog population (described throughout the manuscript as CnNPHV). We examined tissues collected from dogs housed in a rehoming kennel where respiratory disease was endemic. CnNPHV RNA was detected in the tracheal tissues of 48/210 dogs by RT-PCR, and in the liver, lung and/or tracheal tissues of 12/20 dogs. The presence of CnNPHV RNA, and its tropism was confirmed by in situ hybridisation. Histopathological examination demonstrated a trend toward higher histopathological scores in CnNPHV RNA positive respiratory tissues, although, this was not statistically significant. Our findings broaden the geographic distribution and our understanding of CnNPHV. Further evidence of CnNPHV replication in canids warrants investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26086431/