Peer-reviewed veterinary case report
Detecting p-ANCA and ANA antibodies in dogs with inflammatory bowel
By Mancho, Carolina et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2010·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Detection of perinuclear antineutrophil cytoplasmic antibodies and antinuclear antibodies in the diagnosis of canine inflammatory bowel disease.
- Species:
- dog
Plain-English summary
A group of dogs with digestive issues was tested for specific antibodies to help diagnose inflammatory bowel disease (IBD). The test looked for perinuclear antineutrophil cytoplasmic antibodies (p-ANCA), which can indicate IBD, and found that most dogs with IBD had these antibodies, while only one also had antinuclear antibodies (ANA). This suggests that testing for p-ANCA could be a useful addition to diagnosing IBD and distinguishing it from other similar gastrointestinal problems. Overall, the findings indicate that p-ANCA testing could help vets better identify IBD in dogs.
People also search for: dog inflammatory bowel disease symptoms · dog digestive issues test · p-ANCA test for dogs
Abstract
In recent years, serologic markers for diagnosis and classification of inflammatory bowel disease (IBD) have been used in human medicine. Perinuclear, antineutrophil, cytoplasmic antibodies (p-ANCA) are the most important of these markers. Because of their similar pattern of fluorescence, antinuclear antibodies (ANA) could cause misleading interpretations. The aim of the present study was to evaluate the use of an indirect fluorescent antibody test to detect p-ANCA in dogs with IBD, to compare the presence of p-ANCA in dogs with IBD with the presence of the same antibodies in other dogs, and to analyze the presence of ANAs in the p-ANCA-positive samples. Using a 110 dilution as a cutoff point, a sensitivity of 0.34 and a specificity of 0.86 was obtained when dogs with IBD were compared with the other groups as a whole, and specificity increased to 0.94 when dogs with IBD were compared with animals with other chronic gastrointestinal disorders. The lowest specificity value, 0.76, was obtained when the group of dogs with IBD was compared with that of dogs with different inflammatory and infectious disorders. Globally, 78 dogs were positive for p-ANCA when the cutoff was 110. Only 1 dog from these 78 animals was also seropositive to ANA. The results suggest that 1) detection of p-ANCA might be included in the IBD diagnostic protocol as another test to differentiate between this disease and other digestive diseases with similar clinical signs, and 2) most p-ANCA-positive dogs are not ANA positive.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20622225/