Peer-reviewed veterinary case report
Testing protective antibodies for cat viruses in shelter cats
By DiGangi, Brian A et al.·Published in Journal of Feline Medicine and Surgery·2011·Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA, United States·View original on Crossref →
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Original publication title: Detection of Protective Antibody Titers against Feline Panleukopenia Virus, Feline Herpesvirus-1, and Feline Calicivirus in Shelter Cats Using a Point-of-Care ELISA
- Species:
- cat
Plain-English summary
A group of shelter cats was tested for protective antibodies against serious viruses like feline panleukopenia, feline herpesvirus, and feline calicivirus. The tests showed that the method used for detecting antibodies against feline panleukopenia was not very reliable, with only 28% sensitivity, meaning it missed many cases. However, the tests for the other two viruses were much more accurate. Improving the detection of panleukopenia antibodies could help shelters manage disease outbreaks more effectively.
People also search for: cat vaccination for panleukopenia · feline herpesvirus symptoms · shelter cat disease prevention
Abstract
Serum antibody titers are a useful measurement of protection against infection (feline panleukopenia virus [FPV]) or clinical disease (feline herpesvirus-1 [FHV] and feline calicivirus [FCV]), and their determination has been recommended as part of disease outbreak management in animal shelters. The objective of this study was to determine the sensitivity, specificity, and inter-observer and inter-assay agreement of two semi-quantitative point-of-care assays for the detection of protective antibody titers (PAT) against FPV, FHV and FCV in shelter cats. Low sensitivity for FPV antibodies (28%) rendered a canine point-of-care assay inappropriate for use in cats. The feline point-of-care assay also had low sensitivity (49%) and low negative predictive value (74%) for FPV PAT detection, but was highly accurate in the assessment of FHV and FCV PAT. Improvements in accuracy and repeatability of FPV PAT determination could make this tool a valuable component of a disease outbreak response in animal shelters.
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Search related cases →Original publication on Crossref: https://doi.org/10.1016/j.jfms.2011.07.009