Peer-reviewed veterinary case report
Detection of Protective Antibody Titers against Feline Panleukopenia Virus, Feline Herpesvirus-1, and Feline Calicivirus in Shelter Cats Using a Point-of-Care ELISA
- Journal:
- Journal of Feline Medicine and Surgery
- Year:
- 2011
- Authors:
- DiGangi, Brian A et al.
- Affiliation:
- Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA · United States
- Species:
- cat
Abstract
Serum antibody titers are a useful measurement of protection against infection (feline panleukopenia virus [FPV]) or clinical disease (feline herpesvirus-1 [FHV] and feline calicivirus [FCV]), and their determination has been recommended as part of disease outbreak management in animal shelters. The objective of this study was to determine the sensitivity, specificity, and inter-observer and inter-assay agreement of two semi-quantitative point-of-care assays for the detection of protective antibody titers (PAT) against FPV, FHV and FCV in shelter cats. Low sensitivity for FPV antibodies (28%) rendered a canine point-of-care assay inappropriate for use in cats. The feline point-of-care assay also had low sensitivity (49%) and low negative predictive value (74%) for FPV PAT detection, but was highly accurate in the assessment of FHV and FCV PAT. Improvements in accuracy and repeatability of FPV PAT determination could make this tool a valuable component of a disease outbreak response in animal shelters.
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Search related cases →Original publication: https://doi.org/10.1016/j.jfms.2011.07.009