Peer-reviewed veterinary case report
Determination of bromide in canine plasma using ion chromatography.
- Journal:
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Year:
- 2008
- Authors:
- Cox, S K et al.
- Affiliation:
- University of Tennessee · United States
- Species:
- dog
Abstract
A new ion chromatographic procedure has been developed and validated for the determination of bromide in canine plasma. Following a simple dilution, samples were separated on a Metrosep A Supp 5 column. The mobile phase was an isocratic mixture of 2.2 mM Na(2)CO(3), 1.0 mM NaHCO(3), and 1% acetonitrile, with a flow-rate of 0.7 ml/min. The procedure produced a linear curve over the concentration range of 50-2500 microg/ml. The development of the assay permitted the determination of therapeutic levels after oral administration of potassium bromide to dogs being treated for epilepsy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18599370/