Peer-reviewed veterinary case report
Best dose of vasopressin to raise blood pressure in dogs
By Yoo, Jong-Hyun et al.·Published in The Journal of veterinary medical science·2007·Konkuk University, South Korea·View original on PubMed →
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Original publication title: Determination of optimal dose of arginine vasopressin in hemorrhagic shock in dogs.
- Species:
- dog
Plain-English summary
A group of dogs experiencing severe blood loss (hemorrhagic shock) was treated with different doses of vasopressin, a medication that helps raise blood pressure. The study found that a dose of 0.4 IU/kg was the most effective for improving blood pressure and overall blood flow compared to lower and higher doses. Dogs receiving this optimal dose showed better hemodynamic stability, which is crucial during such critical conditions. This suggests that if your dog is in shock, a specific dose of vasopressin could significantly help their recovery.
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Abstract
The hemodynamic effects of vasopressin of high/low doses on dogs were investigated using experimentally induced hemorrhagic shock model. Experimental groups were categorized according to administered doses of vasopressin (0.1, 0.4 and 1.6 IU/kg) and hemodynamic parameters were measured before and after the graded-dose administration of vasopressin. Administration of high- and middle-dose vasopressin (0.4 and 1.6 IU/kg) showed superior increase in blood pressure and systemic vascular resistance, compared with those of low-dose one (0.1 IU/kg). Results of systolic arterial pressure and mean arterial pressure in 1.6 IU/kg-administered group revealed lower efficacy than that in 0.4 IU/kg group in spite of administration of higher dose. This study demonstrates that 0.4 IU/kg of vasopressin can be used as the most effective dose for improving hemodynamic condition in the decompensatory phase of hemorrhagic shock in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17675809/