Peer-reviewed veterinary case report
Determination of the infectious titer and virulence of an original US porcine epidemic diarrhea virus PC22A strain.
- Journal:
- Veterinary research
- Year:
- 2015
- Authors:
- Liu, Xinsheng et al.
- Affiliation:
- College of Food · United States
Abstract
The infectious dose of a virus pool of original US PEDV strain PC22A was determined in 4-day-old, cesarean-derived, colostrum-deprived (CDCD) piglets. The median pig diarrhea dose (PDD50) of the virus pool was determined as 7.35 log10 PDD50/mL, similar to the cell culture infectious titer, 7.75 log10 plaque-forming units (PFU)/mL. 100 PDD50 caused watery diarrhea in all conventional suckling piglets (n = 12) derived from a PEDV-naive sow, whereas 1000 and 10 000 PDD50 did not cause diarrhea in piglets derived from two PEDV-field exposed-recovered sows. This information is important for future PEDV challenge studies and validation of PEDV vaccines.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26408019/