Peer-reviewed veterinary case report
Best propofol drip rate for safe dog anesthesia induction
By Walters, Kate et al.·Published in Veterinary anaesthesia and analgesia·2022·The Queen's Veterinary School Hospital, United Kingdom·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Determining an optimum propofol infusion rate for induction of anaesthesia in healthy dogs: a randomized clinical trial.
- Species:
- dog
Plain-English summary
A group of 60 healthy dogs undergoing routine procedures like neutering and X-rays were given different rates of a medication called propofol to see which rate allowed for quicker intubation while minimizing breathing pauses afterward. The results showed that a propofol infusion rate of 1.0 mg per kg per minute was the best choice, leading to faster intubation times and shorter periods of not breathing compared to higher rates. This means that using this specific rate can help keep dogs safe and comfortable during anesthesia.
People also search for: dog anesthesia propofol rate · why is my dog not breathing after surgery · neutering dog anesthesia safety
Abstract
OBJECTIVE: To determine an optimum infusion rate of propofol that permitted rapid tracheal intubation while minimizing the duration of postinduction apnoea. STUDY DESIGN: Prospective, randomized, blinded clinical trial. ANIMALS: A total of 60 client-owned dogs presented for elective neutering and radiography. METHODS: Dogs were randomly allocated to one of five groups (groups A-E) to have propofol at an infusion rate of 0.5, 1, 2, 3, or 4 mg kgminute, respectively, following intramuscular premedication with methadone 0.5 mg kgand dexmedetomidine 5 μg kg. Propofol administration was stopped when adequate conditions for tracheal intubation were identified. Time to tracheal intubation and duration of apnoea were recorded. If oxygen haemoglobin saturation decreased to < 90%, manual ventilation was initiated. A one-way analysis of covariance was conducted to compare the effect of propofol infusion rate on duration of apnoea and intubation time whilst controlling for covariates, followed by post hoc tests. The significance level was set at p < 0.05. RESULTS: Propofol infusion rate had a significant effect on duration of apnoea (p = 0.004) and intubation time (p < 0.001) after controlling for bodyweight and sedation scores, respectively. The adjusted means (± standard error) of duration of apnoea were significantly shorter in groups A and B (49 ± 39 and 67 ± 37 seconds, respectively) than in groups C, D and E (207 ± 34, 192 ± 36 and 196 ± 34 seconds, respectively). Group B (115 ± 10 seconds) had a significantly shorter intubation time than group A (201 ± 10 seconds, p < 0.001). CONCLUSIONS AND CLINICAL RELEVANCE: An infusion rate of 1.0 mg kgminute(group B) appears to offer the optimal compromise between speed of induction and duration of postinduction apnoea.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35221200/