Peer-reviewed veterinary case report
New bleeding score to assess immune thrombocytopenia in dogs
By Makielski, Kelly M et al.·Published in Journal of veterinary internal medicine·2018·Department of Veterinary Clinical Sciences·View original on PubMed →
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Original publication title: Development and implementation of a novel immune thrombocytopenia bleeding score for dogs.
- Species:
- dog
Plain-English summary
A group of dogs with low platelet counts, which can lead to bleeding issues, were evaluated using a new scoring system called DOGiBAT to measure the severity of their bleeding. This system helps veterinarians consistently assess how much a dog is bleeding based on specific criteria. The study found that the DOGiBAT score was linked to how low the platelet count was and how much treatment, like blood transfusions, was needed. This tool could help vets better understand and manage dogs with immune thrombocytopenia (ITP) in the future.
People also search for: dog bleeding problems · immune thrombocytopenia treatment for dogs · low platelet count in dogs
Abstract
BACKGROUND: A method of quantifying clinical bleeding in dogs with immune thrombocytopenia (ITP) is needed because ITP patients have variable bleeding tendencies that inconsistently correlate with platelet count. A scoring system will facilitate patient comparisons and allow stratification based on bleeding severity in clinical trials. HYPOTHESIS/OBJECTIVES: To develop and evaluate a bleeding assessment tool for dogs, and a training course for improving its consistent implementation. ANIMALS: Client-owned dogs (n = 61) with platelet counts <50,000/μL; 34 classified as primary ITP, 17 as secondary ITP, and 10 as non-ITP. METHODS: A novel bleeding assessment tool, DOGiBAT, comprising bleeding grades from 0 (none) to 2 (severe) at 9 anatomic sites, was developed. Clinicians and technicians completed a training course and quiz before scoring thrombocytopenic patients. The training course was assessed by randomizing student volunteers to take the quiz with or without prior training. A logistic regression model assessed the association between training and quiz performance. The correlation of DOGiBAT score with platelet count and outcome measures was assessed in the thrombocytopenic dogs. RESULTS: Clinicians and technicians consistently applied the DOGiBAT, correctly scoring all quiz cases. The odds of trained students answering correctly were higher than those of untrained students (P < .0001). In clinical cases, DOGiBAT score and platelet count were inversely correlated (r = -0.527, P < .0001), and DOGiBAT directly correlated with transfusion requirements (r = 0.512, P < .0001) and hospitalization duration (r = 0.35, P = .006). CONCLUSIONS AND CLINICAL IMPORTANCE: The DOGiBAT and assessment quiz are simple tools to standardize evaluation of bleeding severity. With further validation, the DOGiBAT may provide a clinically relevant metric to characterize ITP severity and monitor response in treatment trials.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29681130/