Peer-reviewed veterinary case report
Development of a murine model of chronic rhinosinusitis.
- Journal:
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
- Year:
- 2006
- Authors:
- Lindsay, Robin et al.
- Affiliation:
- and the Uniformed Services University of the Health Sciences · United States
- Species:
- rodent
Abstract
OBJECTIVE: The aim of this study was to develop a mouse model of chronic eosinophilic rhinosinusitis. STUDY DESIGN: Mice were sensitized to Aspergillis fumigatus (Af) extract by intraperitoneal injection. The animals subsequently received nasal challenges with Af extract 3 times per week for 12 weeks. Sinonasal complexes were studied histologically by the study otolaryngologists and pathologists to characterize the inflammatory response. SETTING: Animal care facility at an academic institution. RESULTS: A chronic eosinophilic inflammatory response was evoked in all study animals. Statistical analysis was performed for inflammation, secretory cell hyperplasia, mast cells, and eosinophils. There were very significant differences (P<0.0005) between control and study mice in all categories. CONCLUSION: Prolonged nasal challenge of Af extract creates an inflammatory response in murine nasal mucosa that mimics human chronic eosinophilic rhinosinusitis. SIGNIFICANCE: A murine model for chronic rhinosinusitis is reported that may facilitate future investigations into disease pathophysiology. EBM RATING: B-2.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16647523/