Peer-reviewed veterinary case report
Development of Mouse Model Systems of Germinal Center Lymphomas.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2017
- Authors:
- Kabrani, Eleni & Sander, Sandrine
- Affiliation:
- Immune Regulation and Cancer · Germany
- Species:
- rodent
Abstract
Germinal centers (GC) are the predominant origin of human B cell lymphomagenesis. Transgenic mice in which gene expression is altered specifically in GC B cells have broadened our knowledge about the mechanisms of malignant transformation. However, extensive resources are needed due to the genetic complexity of these mouse models. Thus, bone marrow (BM)-derived chimerism is an attractive approach to study GC B cell derived lymphomagenesis, as it allows for an efficient allocation of resources and reduces the number of animals used.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28589360/