Peer-reviewed veterinary case report
Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.
- Journal:
- Journal of virology
- Year:
- 2012
- Authors:
- Dang, Que et al.
- Affiliation:
- National Institute of Allergy and Infectious Diseases · United States
Abstract
Simian immunodeficiency virus (SIV) infection of macaques can result in central nervous system disorders, such as meningitis and encephalitis. We studied 10 animals inoculated with brain-derived virus from animals with SIV encephalitis. Over half of the macaques developed SIV-induced neurologic disease. Elevated levels of systemic immune activation were observed to correlate with viral RNA in the cerebral spinal fluid but not with plasma viral load, consistent with a role for SIV in the pathogenesis of neurologic disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23035225/