Development of new concepts in vaccines and their effects on the control of infectious diseases (classical swine fever in particular).

Abstract

Molecular biology and technological advances in DNA recombination have ushered in a new era in vaccinology. In particular, "deleted" vaccines have emerged over the past 10 years. The first such vaccines were used to protect pigs against Aujeszky's disease. The same principles were subsequently applied to the development of vaccines against classical swine fever (CSF), relaunching the debate on whether to use sanitary or medical measures. The decision about the measures to be applied depends on several criteria and factors such as the capabilities of the vaccines to be used in an emergency situation and the local epidemiological situation. Under the light of the last CSF serious epizootic which appeared in Europe in 1997, the effects of the different types of measures are discussed.