Peer-reviewed veterinary case report
Non-lung soft-tissue spread doesn't worsen outlook in dogs with bone
By Fontes, Gabrielle S et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2024·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Development of non-pulmonary soft-tissue metastasis is not a poor prognostic indicator in dogs with metastatic appendicular osteosarcoma.
- Species:
- dog
Plain-English summary
A group of dogs with appendicular osteosarcoma (a type of bone cancer) were treated with surgery and chemotherapy. Some of these dogs developed non-pulmonary soft-tissue metastases (cancer spread to other soft tissues outside the lungs), while others had metastases in the lungs or bones. Surprisingly, the dogs with soft-tissue metastases had similar survival times and outcomes as those with lung or bone metastases. This suggests that having non-pulmonary metastases does not necessarily mean a worse prognosis for dogs with this type of cancer.
People also search for: dog osteosarcoma treatment · dog cancer survival rates · non-pulmonary metastasis in dogs
Abstract
OBJECTIVES: To evaluate whether patient factors affect development of non-pulmonary soft-tissue metastases following treatment of canine appendicular osteosarcoma and to report and compare outcomes to those in dogs with pulmonary or osseous metastases. ANIMALS AND PROCEDURE: The records of 3 veterinary teaching hospitals were reviewed to identify dogs that received definitive treatment for a primary appendicular osteosarcoma lesion and chemotherapy between January 2010 and June 2022. Dogs with non-pulmonary metastases following initial treatment were included. Descriptive statistics were calculated to summarize signalment information, and metastasis and survival times were compared between groups using Kaplan-Meier survival analysis and log-rank tests. RESULTS: Thirty-six and 109 dogs developed non-pulmonary soft-tissue metastases and pulmonary or osseous metastases, respectively, following initial treatment. No patient factors were significantly associated with development of non-pulmonary soft-tissue metastases. The median times to non-pulmonary soft-tissue metastasis or initial pulmonary or osseous metastasis were 220 and 169 d, respectively (= 0.18); whereas overall median survival times were 250 and 270 d, respectively (= 0.36). CONCLUSION: Dogs with non-pulmonary soft-tissue metastases had similar disease-free intervals and survival rates to dogs with typical pulmonary or osseous metastases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39355701/