Peer-reviewed veterinary case report
Rapid test developed to detect leptospirosis antibodies in dogs
By Subathra, M et al.·Published in Comparative immunology, microbiology and infectious diseases·2011·Department of Animal Biotechnology, India·View original on PubMed →
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Original publication title: Development of rapid flow-through-based dot-immunoassay for serodiagnosis of leptospirosis in dogs.
- Species:
- dog
Plain-English summary
A new test for diagnosing leptospirosis in dogs was developed using a rapid flow-through method. This test checks for antibodies against the leptospira bacteria, which can cause serious illness in pets. The new test showed good accuracy, with a sensitivity of about 88% and specificity of around 90%, making it a reliable option for screening. Compared to traditional testing methods, this rapid test could help veterinarians diagnose leptospirosis more quickly and effectively, allowing for timely treatment.
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Abstract
An IgG-ELISA used recombinant antigen and a rapid flow-through enzyme immunoassay were developed for rapid screening of leptospiral antibodies in dogs using recombinant LipL41, which is one of the conserved outer membrane proteins in pathogenic leptospires as the coating antigen. Results from this study were compared with the standard microscopic agglutination test and found that the sensitivity and specificity of the enzyme-linked immunosorbent assay were 75.46% and 93.29% and whereas that of flow-through-based dot-immunobinding assay were 87.73% and 89.63%, respectively. Relative merits of these tests were also assessed. The flow-through-based dot-immunobinding assay was thus proved to be a valid screening test for canine leptospirosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19906426/