Peer-reviewed veterinary case report
Dexmedetomidine lowers propofol dose for intubation in Beagles
By Li, Xiaona et al.·Published in Journal of the American Veterinary Medical Association·2022·View original on PubMed →
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Original publication title: Dexmedetomidine decreases the 50% effective dose (ED50) of intravenous propofol required to prevent tracheal intubation response in Beagles.
- Species:
- dog
Plain-English summary
A group of 36 adult male Beagles were given either a sedative called dexmedetomidine or a placebo before being put under anesthesia with propofol for a procedure. The study found that the dogs that received dexmedetomidine needed less propofol to prevent a response during tracheal intubation, which is when a tube is placed in the airway. This means that using dexmedetomidine can help reduce the amount of propofol needed, potentially leading to fewer breathing issues during recovery. The dogs that received the higher dose of dexmedetomidine took longer to wake up compared to the others.
People also search for: Beagle anesthesia propofol dosage · dexmedetomidine for dogs · dog intubation recovery time
Abstract
OBJECTIVE: To determine the 50% effective dose (ED50) of intravenous propofol required for successfully preventing tracheal intubation response in Beagles co-induced with dexmedetomidine. ANIMALS: 36 adult male Beagles. PROCEDURES: The dogs were randomly assigned to either group D1, group D2, or group C (received 1 µg/kg, 2 µg/kg dexmedetomidine intravenously, or the same amount of normal saline as dexmedetomidine, 10 mL). The first dog in each group received 6 mg/kg of propofol for induction. The pump speed of propofol was 600 mL/h. The dosage varied with increments or decrements of 0.5 mg/kg based on the Dixon up-and-down method. The duration of eye-opening after propofol administration was recorded. Changes in heart rate (HR) and respiratory rate (RR) were recorded at 5 timepoints: after entering the operation room and prior to propofol administration (T1), 1 and 3 min after propofol administration (T2 and T3), 3 and 5 min after intubation (T4 and T5). RESULTS: The required ED50 of propofol that prevented tracheal intubation response in D1, D2, and C groups were 6.4 mg/kg (95% CI, 6.1 to 6.7 mg/kg), 5.8 mg/kg (95% CI, 5.67 to 6 mg/kg), and 8.3 mg/kg (95% CI, 8 to 8.5 mg/kg), respectively. The recovery time of group D2 was significantly longer than that of groups D1 and C (P < .05). The differences in HR among the 3 groups were significant from T2 up to T5 timepoint (P < .05). The differences in RR among the 3 groups were significant at T2 and T3 timepoints (P < .05). CLINICAL RELEVANCE: Dexmedetomidine pre-injection reduces the amount of propofol required for endotracheal intubation response in Beagles, thereby reducing the respiratory inhibition induced by propofol.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36315451/