Peer-reviewed veterinary case report
How squash cytology helps diagnose stomach cancer in dogs
By Riondato, Fulvio et al.·Published in Veterinary journal (London, England : 1997)·2014·Department of Veterinary Sciences, Italy·View original on PubMed →
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Original publication title: Diagnosis of canine gastric adenocarcinoma using squash preparation cytology.
- Species:
- dog
Plain-English summary
A study found that dogs with gastric adenocarcinoma, a type of stomach cancer, often show non-specific symptoms, making diagnosis challenging. By examining gastric biopsy samples using a method called squash preparation cytology, researchers identified key features like signet ring cells and microvacuolation that are strongly linked to this cancer. This approach can help veterinarians diagnose gastric adenocarcinoma more quickly and accurately compared to traditional methods. Early diagnosis can lead to timely treatment, improving outcomes for affected dogs.
People also search for: dog stomach cancer symptoms · gastric adenocarcinoma diagnosis in dogs · canine biopsy results interpretation
Abstract
Adenocarcinoma is the most common gastric tumour in dogs. Clinical signs and laboratory results are often non-specific, with histopathological examination of gastric biopsies being required to reach a definitive diagnosis. Use of cytology would potentially shorten the time to diagnosis and allow early interventional measures to be implemented. However, there are relatively few studies of the cytological features of gastric samples. The present study was designed to investigate whether cytology might be useful for diagnosis of canine gastric adenocarcinomas and to evaluate the performance of squash preparation cytology for this purpose. Squash preparations of gastric biopsies from 94 dogs were reviewed to determine the presence or absence of specific cytological features associated with adenocarcinomas and to compare findings with the results of histopathological examination of gastric biopsies. The presence of signet ring cells, microvacuolation, cellular pleomorphism and single cell distribution of epithelial cells were positively associated with a diagnosis of gastric adenocarcinoma. Combined evaluation (parallel testing) for the presence of signet ring cells and microvacuolation demonstrated excellent results for recognition of adenocarcinomas. Cytological examination of squash preparations from gastric biopsies and identification of signet ring cells and cytoplasmic vacuolation can allow rapid and reliable diagnosis of canine gastric adenocarcinomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24923753/