Peer-reviewed veterinary case report
Diagnosing nasal hamartoma tumors in young cats using cytology
By Bottero, Enrico et al.·Published in Veterinary clinical pathology·2018·Professional Association Endovet, Italy·View original on PubMed →
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Original publication title: Diagnosis of feline mesenchymal nasal hamartoma by squash preparation cytology.
- Species:
- cat
Plain-English summary
A young cat was diagnosed with a rare nasal growth called mesenchymal nasal hamartoma after showing signs of nasal obstruction. The diagnosis was confirmed through a special test that looked at cells from a biopsy taken during an endoscopy. Two cytologists examined the samples and found specific types of cells that are commonly associated with this condition. Their findings suggest that these cell types can help vets diagnose this nasal issue more easily. The cat received appropriate treatment based on the diagnosis, which can lead to a better outcome.
People also search for: cat nasal growth diagnosis · feline nasal obstruction symptoms · mesenchymal nasal hamartoma treatment
Abstract
BACKGROUND: Feline Mesenchymal Nasal Hamartoma (MNH) is a rare benign tumor-like lesion of the sinonasal tract affecting young cats. OBJECTIVES: This study aimed to determine the diagnostic significance of osteoblast-like (OB-L) and osteoclast-like cells (OC-L) in squash preparation cytology from endoscopic biopsies. METHODS: A 5-year database was retrospectively reviewed and included 109 cases of which 24 were diagnosed as MNH by histopathology. Slides were examined by two cytologists (one experienced and one inexperienced in nasal and squash cytology) in a double-blind study. The inexperienced cytologist counted OB-L and OC-L in 500 intact nucleated cells. The experienced cytologist assigned samples to four categories for OB-L (0, 1-5, 6-10, >10/field) and OC-L (0, 1-2, 3-5, >5/field). RESULTS: The presence of OB-L and OC-L was significantly associated (P < 0.001) with the histologic diagnosis of MNH. Receiver operating characteristic curves from the counts by the inexperienced cytologist revealed 3/500 OB-L and 2/500 OC-L as the best cut-offs for the diagnosis of MNH. Those of the experienced cytologist evaluation revealed that all the MNHs presented more than 10 OB-L/field and 3 or more OC-L/field. Both cytologists detected each cell type in all MNHs with an overall concordance of 0.93. CONCLUSIONS: The presence of OB-L and OC-L is a consistent finding in MNH, and thus, represents a reliable cytologic diagnostic criterion. The described methods are applicable in routine in-clinic laboratory settings and are easy to apply at any expertise level. Further prospective studies are needed to assess the accuracy of the proposed cut-off values.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30379340/