Peer-reviewed veterinary case report
How to diagnose pancreatitis in cats with SNAP fPL and Spec fPL tests
By Schnauß, Fanny et al.·Published in Journal of feline medicine and surgery·2019·1 Small Animal Clinic, Germany·View original on PubMed →
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Original publication title: Diagnosis of feline pancreatitis with SNAP fPL and Spec fPL.
- Species:
- cat
Plain-English summary
A group of cats suspected of having pancreatitis showed symptoms like lethargy, reduced appetite, vomiting, and dehydration. Researchers compared two tests, SNAP fPL and Spec fPL, to see which was better at diagnosing the condition. They found that while both tests were effective, using SNAP fPL first could help quickly rule out pancreatitis in emergency situations. This approach allowed veterinarians to make more accurate diagnoses and decide on the best treatment for the cats.
People also search for: cat vomiting and lethargy · pancreatitis test for cats · SNAP fPL vs Spec fPL · cat dehydration treatment · feline pancreatitis symptoms
Abstract
OBJECTIVES: Pancreatitis is a frequent disease in cats for which the ante-mortem diagnosis remains challenging. Feline pancreatic lipase immunoreactivity (fPLI) has been reported to have a high sensitivity for the diagnosis of pancreatitis. The aim of this study was to compare the rapid in-house test SNAP fPL with the standard test Spec fPL and to evaluate the use of SNAP fPL to diagnose pancreatitis in an emergency setting. METHODS: fPLI of 111 cats with a clinical suspicion of pancreatitis was measured with both SNAP fPL and Spec fPL. Furthermore, clinical signs, haematological and biochemical changes, and abdominal ultrasound findings were recorded. RESULTS: Seventy-eight of 111 cats (70.3%) were tested below the cut-off level for pancreatitis with SNAP, as well as Spec fPL, whereas 21/111 (18.9%) were tested with values above the cut-off level with both tests. In 12/111 (10.8%) cats the results were discordant. The comparison of both tests revealed an agreement of 78/80 (97.5%) when Spec fPL was ⩽3.5 μg/l (negative) and 18/20 (90%) when Spec fPL was ⩾5.4 μg/l (positive). The most common clinical signs in cats with suspected pancreatitis (n = 21) were lethargy (95.2%), reduced appetite and vomiting (90.5% each), dehydration (81.0%), diarrhoea (57.1%), abdominal pain and weight loss (47.6% each). Hyperglycaemia and hyperbilirubinaemia (85.7% each), increased aspartate transaminase (76.2%) and alanine transaminase (47.6%), leucocytosis (61.9%), lymphopenia (57.1%), decreased sodium and chloride (57.1% each), and increased urea (52.4%) were the most common abnormalities in blood work. CONCLUSIONS AND RELEVANCE: Clinical signs, as well as routine blood-work changes, were non-specific and thus proved to be insufficient to diagnose pancreatitis. The combination of SNAP fPL and subsequent Spec fPL, if indicated, provided the opportunity to rule out or to diagnose pancreatitis with a higher certainty than previously known test methods. This study proved SNAP fPL to be a valuable tool to exclude or include pancreatitis in an emergency setting.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30183482/