Peer-reviewed veterinary case report
Puppies with brain disease diagnosed with infectious canine hepatitis
By Caudell, D et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2005·Department of Veterinary Pathobiology, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Diagnosis of infectious canine hepatitis virus (CAV-1) infection in puppies with encephalopathy.
- Species:
- dog
Plain-English summary
Nine Labrador Retriever puppies were brought in showing severe signs of central nervous system problems, including difficulty walking and blindness. Unfortunately, all the puppies passed away. A closer examination of their tissues revealed bleeding in the brain and swollen lymph nodes. Tests confirmed that they were infected with canine adenovirus-1, which causes infectious canine hepatitis. This tragic case highlights the seriousness of this virus in young puppies.
People also search for: puppy blindness causes · Labrador Retriever ataxia · infectious canine hepatitis symptoms · puppy brain disease treatment
Abstract
Nine weaned Labrador Retriever puppies from a litter of 11 were presented with signs of acute central nervous system (CNS) disease that included ataxia and blindness. All puppies died. Gross examination of tissues from 2 puppies revealed regionally diffuse hemorrhages in the brain stem and swollen hemorrhagic lymph nodes. Light microscopic examination of hematoxylin and eosin-stained tissues showed numerous large, basophilic intranuclear inclusion bodies within CNS vascular endothelium and occasionally in individual hepatocytes. Immunohistochemical staining of the tissue was positive using an antibody against canine adenovirus-1. Virus isolation for infectious canine hepatitis virus was achieved using inoculated cell cultures. Polymerase chain reaction amplification of DNA from cell culture material revealed shared homology with other mammalian adenoviruses.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15690952/