Peer-reviewed veterinary case report
Accuracy of SNAP and Spec pancreatic tests for dogs with sudden belly
By Haworth, Mark D. et al.·Published in Journal of Veterinary Emergency and Critical Care·2014·School of Veterinary and Biomedical Sciences Murdoch University Perth Western Australia Australia, Australia·View original on Crossref →
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Original publication title: Diagnostic accuracy of the SNAP and Spec canine pancreatic lipase tests for pancreatitis in dogs presenting with clinical signs of acute abdominal disease
- Species:
- dog
Plain-English summary
A group of 38 dogs with sudden stomach issues was tested for pancreatitis (inflammation of the pancreas) using two different blood tests: SNAP canine pancreatic lipase (cPL) and Spec canine pancreatic lipase (Spec cPL). The SNAP test was fairly accurate, correctly identifying pancreatitis in about 82% of dogs that had it, while the Spec test was accurate for about 70%. However, both tests could give false positives, meaning they might suggest pancreatitis when it isn't present in some dogs. Overall, the tests showed good agreement with each other, but pet owners should be aware that a positive result doesn't always mean their dog has pancreatitis.
People also search for: dog stomach pain pancreatitis test · SNAP cPL accuracy · Spec cPL false positive dogs
Abstract
AbstractObjectivesTo (i) assess the clinical diagnostic accuracy of SNAP canine pancreatic lipase (cPL) and specific canine pancreatic lipase (Spec cPL) and (ii) assess the agreement of an abnormal test result between SNAP cPL and Spec cPL in dogs presenting with acute abdominal disease.DesignProspective observational cohort study.SettingUniversity teaching hospital emergency center.AnimalsThirty‐eight client‐owned dogs that presented with acute abdominal disease, with a known final diagnosis between March 2009 and April 2010. Dogs were retrospectively assigned into 2 groups, dogs with acute pancreatitis (AP) (Group 1) and dogs without AP (Group 2).InterventionsPaired serum samples obtained within 24 hours of presentation were analyzed using the SNAP cPL test and Spec cPL assay.Measurements and ResultsSNAP cPL clinical sensitivity and specificity was 82% (9/11 dogs of group 1) and 59% (16/27 dogs of group 2), respectively. Spec cPL clinical sensitivity and specificity was 70% (7/10 dogs of group 1) and 77% (20/26 dogs of group 2), respectively. Accuracy of the SNAP and Spec cPL for a clinical diagnosis of pancreatitis was found to be 66% and 75%, respectively. Agreement between a positive SNAP (cPL ≥ 200 μg/L) and a clinical diagnosis pancreatitis resulted in κ = 0.33. Agreement between an increased Spec (cPL ≥ 400 μg/L) and a clinical diagnosis of pancreatitis resulted in a κ = 0.43. The agreement between SNAP and Spec cPL (cPL ≥ 200 μg/L) for the entire cohort resulted in κ = 0.78.ConclusionSNAP cPL and Spec cPL results may provide a "false positive" diagnosis of pancreatitis in up to 40% of dogs presenting with acute abdominal disease. There is good overall agreement between SNAP cPL and Spec cPL; however, there were 4/38 dogs with positive SNAP cPL and "normal" Spec cPL.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vec.12158