Peer-reviewed veterinary case report
Endothelin-1 blood levels linked to heart and lung disease in dogs
By Tessier-Vetzel, D et al.·Published in The Veterinary record·2006·Unité, France·View original on PubMed →
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Original publication title: Diagnostic and prognostic value of endothelin-1 plasma concentrations in dogs with heart and respiratory disorders.
- Species:
- dog
Plain-English summary
A group of dogs with heart and breathing problems had their blood tested for a substance called endothelin-1 (ET-1) to see if it could help diagnose their conditions. The study found that dogs with these issues had much higher levels of ET-1 compared to healthy dogs. Higher ET-1 levels were linked to more severe heart failure and worse respiratory problems. This test could help vets tell apart heart and breathing disorders in dogs that show symptoms during exercise.
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Abstract
The endothelin-1 (ET-1) plasma concentration was measured in dogs with spontaneous cardiac or respiratory diseases. Plasma samples were obtained from 76 healthy control dogs and 73 dogs, of which 58 were suffering from heart disease and 15 were suffering from respiratory disease. Dogs were evaluated using echocardiography, thoracic radiography, biochemical evaluation and a radioimmunoassay for ET-1. ET-1 plasma concentrations were significantly higher in dogs with spontaneous cardiac or respiratory diseases (mean [se] 5.3 [0.3] and 5.3 [0.6] pg/ml, respectively) than in healthy dogs (1.9 [0.1] pg/ml) (P<0.0001). ET-1 plasma concentrations increased with the class of heart failure (International Small Animal Cardiac Health Council classification) (P<0.0001) and with the severity of pulmonary disorders. ET-1 plasma concentrations were positively correlated with the extent of systolic pulmonary hypertension measured by Doppler echocardiography (P<0.05; r=0.75) and with the clinical outcome of dogs with respiratory disease. Evaluation of the ET-1 plasma concentration allowed differentiation between heart and respiratory disorders in dogs exhibiting clinical signs at exercise, but not in patients exhibiting clinical signs at rest.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16766723/