Peer-reviewed veterinary case report
Dog in Ontario diagnosed with tuberculosis infection and public
By Luke A. J. Haydock et al.·Published in Journal of Veterinary Diagnostic Investigation·2022·View original on Semantic Scholar →
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Original publication title: Diagnostic and public health investigation of Mycobacterium tuberculosis infection in a dog in Ontario, Canada
- Species:
- dog
Plain-English summary
A 4-year-old female mixed-breed dog was brought to the vet because she had multiple masses in her lungs and liver, swollen lymph nodes in her chest, and fluid in her chest. After several tests, including a biopsy, the dog was diagnosed with a Mycobacterium tuberculosis infection. Unfortunately, her health worsened after surgery, and she was euthanized. A postmortem exam confirmed severe lung and liver disease, and public health officials tested 45 people who had contact with her, finding no human infections linked to the dog. This case emphasizes the need for better testing options for diagnosing similar infections in dogs.
People also search for: dog lung masses · Mycobacterium tuberculosis in dogs · dog euthanasia after surgery · dog liver disease symptoms · public health dog infection concerns
Abstract
A 4-y-old, female mixed-breed dog was presented to the Ontario Veterinary College for further evaluation of multiple pulmonary and hepatic masses, intrathoracic lymphadenitis, and recent development of a pyogranulomatous pleural effusion. Along with other comprehensive tests, a thoracic lymph node biopsy was performed, and Mycobacterium tuberculosis complex infection was confirmed by real-time PCR. The dog’s condition declined post-operatively, and euthanasia was elected. Postmortem examination confirmed severe granulomatous pneumonia, hepatitis, intrathoracic and intraabdominal lymphadenitis, omentitis, and nephritis. Line-probe assays performed on samples collected postmortem confirmed the species as M. tuberculosis. 24-loci MIRU-VNTR genotyping, spoligotyping, and whole-genome sequencing revealed relations to known human isolates, but no epidemiologic link to these cases was investigated. Given the concern for potential human exposure during this animal’s disease course, a public health investigation was initiated; 45 individuals were tested for M. tuberculosis exposure, and no subsequent human infections related to this animal were identified. Our case highlights the need for more readily available, minimally invasive testing for the diagnosis of canine mycobacteriosis, and highlights the ability of canid species to act as potential contributors to the epidemiology of M. tuberculosis infections.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/35075970