Peer-reviewed veterinary case report
Early urine tests to detect kidney injury in dogs with leptospirosis
By Asma Idress, M et al.·Published in Veterinary research communications·2024·Department of Veterinary Epidemiology and Preventive Medicine, India·View original on PubMed →
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Original publication title: Diagnostic efficacy of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for early detection of acute kidney injury in dogs with leptospirosis or babesiosis.
- Species:
- dog
Plain-English summary
A dog with kidney problems caused by leptospirosis or babesiosis may show signs like increased thirst, frequent urination, or lethargy. Researchers found that two specific urine tests, Neutrophil Gelatinase-Associated Lipocalin (uNGAL) and Kidney Injury Molecule-1 (uKIM-1), can help detect early kidney injury in these dogs before traditional tests show issues. These tests were particularly useful for identifying kidney damage when other markers were still normal. Using these urine tests could help veterinarians diagnose and manage kidney injuries more effectively in dogs.
People also search for: dog kidney problems symptoms · leptospirosis treatment in dogs · early signs of kidney injury in dogs
Abstract
This study evaluates the diagnostic efficacy of urinary biomarkers, Neutrophil Gelatinase-Associated Lipocalin (uNGAL), and Kidney Injury Molecule-1 (uKIM-1), in identifying Acute Kidney Injury (AKI) in dogs affected with leptospirosis or babesiosis. Acute kidney injury was diagnosed based on the increase in serum creatinine levels above 0.3 mg/dL within 48 h and dogs were categorized according to AKI grades based on International Renal Interest Society guidelines. Traditional biomarkers (serum creatinine and blood urea nitrogen) and novel biomarkers like urinary NGAL and urinary KIM-1 levels were measured and compared to concentrations obtained in control dogs. Statistical analysis assessed significant differences (P < 0.01) across AKI grades, specifically noting elevated urinary NGAL and KIM-1 in IRIS grade I AKI (P < 0.001). The study highlights the diagnostic significance of urinary NGAL and KIM-1 as early indicators of renal damage, particularly valuable in non-azotemic AKI cases, offering promising markers for early AKI diagnosis in veterinary clinical settings. These biomarkers demonstrate clinical utility and underscore their potential for improving AKI management in veterinary medicine. Further validation studies involving larger cohorts and diverse etiologies of AKI are needed to confirm the diagnostic accuracy and clinical utility of urinary NGAL and KIM-1 in veterinary practice.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38809503/