Peer-reviewed veterinary case report
Dog with blood clotting disorder and vessel inflammation
By Gilor, Chen et al.·Published in Journal of the American Animal Hospital Association·2011·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: DIC and granulomatous vasculitis in a dog with disseminated histoplasmosis.
- Species:
- dog
Plain-English summary
A 7-month-old female mixed-breed dog was brought in with severe health issues and was diagnosed with disseminated histoplasmosis, a serious fungal infection, and disseminated intravascular coagulopathy, a condition affecting blood clotting. The dog showed some improvement with supportive care but worsened after starting antifungal treatment. Unfortunately, the dog's condition continued to decline, leading to euthanasia. A post-mortem examination revealed significant inflammation and damage in her organs caused by the infection.
People also search for: dog histoplasmosis symptoms · antifungal treatment for dogs · why is my dog bleeding · dog granulomatous vasculitis · dog blood clotting issues
Abstract
Disseminated histoplasmosis and disseminated intravascular coagulopathy were diagnosed in a 7 mo old, female spayed mixed-breed dog. The dog improved transiently with supportive care, but deteriorated shortly after initiation of antifungal therapy. The dog was subsequently euthanized. At necropsy, marked granulomatous vasculitis was identified in all affected organs. The tunicae and laminae of the arteries and arterioles were obscured by epithelioid macrophages and multinucleated giant cells admixed with necrotic material. Intracytoplasmic yeast were present within some of these macrophages. To the authors' knowledge, this is the first reported case of granulomatous vasculitis associated with Histoplasma capsulatum in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21531969/