Peer-reviewed veterinary case report
Diet nutrient targets for dogs with ACHES liver syndrome
By John C. Rowe et al.·Published in Pets·2024·Loftus Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA, CH·View original on DOAJ →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Dietary Nutrient Evaluations in a Cohort of Dogs with Aminoaciduric Canine Hypoaminoacidemic Hepatopathy Syndrome Inform Dietary Targets for Protein, Fat, Sodium, and Calcium
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with a rare liver condition called aminoaciduric canine hypoaminoacidemic hepatopathy syndrome (ACHES) were studied to find the best diet for their recovery. The research showed that dogs fed home-cooked meals had higher levels of protein and certain amino acids compared to those on commercial diets, which seemed to help them live longer. Increasing protein and sodium in their diets was linked to a lower risk of death, while higher fat levels were associated with a greater risk. Based on these findings, specific dietary recommendations were made to help manage ACHES effectively.
People also search for: dog liver disease diet · ACHES in dogs treatment · home-cooked meals for dogs with liver problems
Abstract
Aminoaciduric canine hypoaminoacidemic hepatopathy syndrome (ACHES) is a rare syndrome affecting dogs. Nutritional management is a pillar of optimal treatment. Currently, there are no specific published data to inform dietary nutrient composition selections for treating affected dogs. Thus, our goal was to establish nutrient targets for the dietary management of ACHES by comparing nutrient profiles of commercial and home-cooked diets fed to dogs after diagnosis and determine if different nutrient inclusions were associated with survival. This retrospective cohort study evaluated nutrient profiles of commercial diets (<i>n</i> = 10) and home-cooked diets (<i>n</i> = 8) fed to dogs with ACHES. Associations between dietary nutrient inclusions and survival duration were determined using Cox proportional hazard analysis. Home-cooked diets were significantly (<i>p</i> < 0.001) higher in dietary protein and several amino acids than commercial diets. Risks of death were significantly (<i>p</i> < 0.05) lower with increasing dietary protein (hazard ratio 0.92 [CI 0.82–1.0]) and sodium (hazard ratio 0.02 [CI < 0.01–0.38]) and higher for dietary fat (hazard ratios 1.15 [CI 1.02–1.37]). An increased risk of death with increasing dietary calcium did not achieve significance (<i>p</i> = 0.067, hazard ratio 9.92 [CI 1.02–201.0]). These results were used to recommend target dietary nutrient ranges, in g/1000 kcal, of 90–130 for protein, 20–40 for fat, 0.7–1.8 for sodium, and 1.0–2.8 for calcium for dietary ACHES management.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on DOAJ: https://doi.org/10.3390/pets1030016