Differences in Inflammation Patterns Induced by African and AsianIsolates in Mice.

Abstract

Abstractis the causative agent of melioidosis, an emerging tropical disease of high mortality. Sub-Saharan Africa represents potential melioidosis "hotspots"; however, to date, only a few cases have been reported. Here in, we compared the inflammatory patterns induced by astrain recently isolated from a fatal Gabonese case with the Thai reference strain-1026b and-E264. Ex vivo, no differences were observed in terms of cellular responsiveness between strains. However, when compared with the-1026b strain, the Gabonese isolate was significantly less virulent in terms of bacterial dissemination, inflammatory response, and organ damage in mice. Genomic comparison between strains showed differences in regions containing a fimbriae/adhesion virulence protein. In addition to a lack of microbiology facilities, differences in virulence ofstrains might contribute to the diverse global clinical occurrence of melioidosis.