Peer-reviewed veterinary case report
Different antigenicities of the N-terminal region of cellular and scrapie prion proteins.
- Journal:
- Microbiology and immunology
- Year:
- 2013
- Authors:
- Ushiki-Kaku, Yuko et al.
- Affiliation:
- Nippi Research Institute of Biomatrix
- Species:
- rodent
Abstract
Limited information is available about conformational differences between the abnormal isoform of prion protein (PrP(Sc) ) and cellular prion protein (PrP(C) ) under native conditions. To clarify conformational differences between these two isoforms, PrP-deficient mice were immunized with brain homogenates of normal and scrapie-infected animals. All mice generated anti-PrP antibodies. Peptide array analysis of these serum samples revealed a distinctive epitope of PrP(Sc) consisting of QGSPGGN (PrP41-47) at the N-terminus. This study demonstrated a conformational dissimilarity at the N-terminus between PrP(Sc) and PrP(C) , a finding that may provide novel information about conformational features of PrP(Sc) .
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24117858/